The aims of this study were to investigate how the release of tadalafil is influenced by two grades of polyvinylpyrrolidone (Kollidon® 12 PF and Kollidon® VA 64) and various methods of preparing solid dispersions (solvent evaporation, spray drying and hot-melt extrusion).Tadalafil is poorly water-soluble and its high melting point makes i
Non-coding RNAs are much more common than previously thought.However, for the vast majority of non-coding RNAs, the cellular function remains enigmatic.The two long non-coding RNA (lncRNA) genes DLEU1 and DLEU2 map to a critical region at chromosomal band 13q14.3 that is recurrently deleted in solid tumors and hematopoietic malignancies like chroni
There is increasing attention for interest as a powerful, complex, and integrative construct, ranging in appearance from entirely momentary states of interest to longer-term interest pursuits.Developmental models have shown how these situational interests can develop into individual interests over time.As such, these models have helped to integrate
Amphibian distribution on degradated habitat in Pasir Bintang and Manduriang districts of the Gunung Raya Wildlife Reserve, South click here Sumatra Province is caused by human activities, namely illegal logging and coffee plantations.Amphibians are one of the components that make up ecosystems that are very sensitive to environmental changes.This
H.influenzae serotype b (Hib) used to be the commonest cause of bacterial meningitis in young children.The widespread use of Hib conjugate vaccine has profoundly altered the epidemiology of H.influenzae meningitis.This short review reports here on the spectrum of H.influenzae meningitis thirty years after Hib conjugate vaccine was first introduced